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Figure Caption
Fig. 6 Ribbon and sticks representation of the CXCR4 modulators bound to the receptor. In the ribbon and sticks representations, the TMV helix is colored in blue and TMVI in pink. Figures show the binding of ligands AGR1.135 (A) and AGR1.137 (B) Zoom images showing the residues involved in the interaction of both compounds are also shown (right panels).(C) Binding of AGR1.131 represented as sticks with carbon atoms in yellow, oxygen in red, nitrogen in blue and fluorine in green. CXCR4 residues involved in CXCL12 engagement and initial signal transmission are represented as green spheres.
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