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Fig. 3 Contour profiler graphs showing effect of various factors on the responses during the synthesis of (a) FL-cHy-NPs, and (b) HK-cHy-NPs. In each figure contour graphs showing responses against factors ‘i’ PCDA vs. PPS-mPEG2000, ‘ii’ PCDA vs. Drug (FL or HK), and ‘iii’ PPS-mPEG2000 vs. Drug (FL or HK) are shown. Table ‘iv’ shows the set values, predicted values, low (Lo) limit and high (Hi) limit of each response fixed during the preparation of the plots. The shaded portions of each plots show the responses beyond the fixed Lo or Hi limits. The horizontal and vertical black lines showing the optimized conditions of the respective factor where they are crossing ‘y’ and ‘x’ axis, respectively