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Fig. 8 Phenotype of RASD1 cardiac malformation in a knocked down zebrafish. (A) The lateral body and enlarged heart of RASD1 zebrafish, control, n = 7, RASD1 KN, n = 7, white line, venous sinus-arterial distance. (B) Down-regulation efficiency of RASD1 gene. (C) Heart rate (times/10 s), control, n = 7, RASD1 KN, n = 7. (D) BV-SA distance, control, n = 7, RASD1 KN, n = 7. (E) Ventricular shortening fraction analysis, control, n = 7, RASD1 KN, n = 7. (F?H) the ventricle volume of zebrafish in systole and diastole, control, n = 7, RASD1 KN, n = 7, a atrium, v ventricle, s systole, d diastole; white line, the major and minor axes of the ventricles; bar = 200 um.