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ZDB-IMAGE-240708-45

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McKaige et al., 2024 - Mitochondrial abnormalities contribute to muscle weakness in a Dnajb6 deficient zebrafish model

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Fig. 6 Western blot analysis shows dnajb6 double mutants have an increase in Pink1 levels indicating mitochondrial damage. (A) VDAC protein levels were increased at 6 dpf in dnajb6b mutants and double mutants. (B) At 3 mpf VDAC protein levels were significantly increased in dnajb6a single mutants but not in double mutants. (C) Western blot of Pink1 at 6 dpf shows no significant differences between genotypes. (D) Double mutants show significantly higher levels of Pink1 compared to their wildtype siblings at 3 mpf. Values are normalised to wildtype and GAPDH was used as a loading control. Error bars represent SEM for three biological replicates at 6 dpf and eight samples from 3 biological replicates at 3 mpf. Analysis was completed using a one-way ANOVA and two-way Dunnett multiple comparisons test.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.