ZFIN Image: Wang et al., 2023, Fig. 6

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Figure Caption

Fig. 6 Hepatocyte-specific overexpression of Rcl1 partially rescues liver dysplasia in bms1lsq163/sq163mutant but not bms1lzju1/zju1mutant. (A–D) WISH was performed using liver-specific fabp10a probe (A and B) and the area ratio of liver or pancreas to eye was calculated (C and D) in bms1lsq163/sq163mutant and siblings (A) or bms1lzju1/zju1 mutant and siblings (B) with or without the background of TgR1# or TgR3# at 5 dpf. (E and F) Immunofluorescence staining of PH3 and Bhmt (E) and the ratio of PH3-positive hepatocytes to total hepatocytes (F) in WT, bms1lsq163/sq163 mutant, bms1lsq163/sq163/TgR1#, and bms1lsq163/sq163/TgR3# at 3 dpf. Bhmt is a marker of the liver and yolk. Blue signal represents nucleus staining by DAPI. Scale bar, 40 μm. NS, no significance; ***P < 0.001.

Acknowledgments

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