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Fig. 5 Proposed model of the role of E2 in obesity metabolism. (A) E2 supplementation independent of unsaturated fat intake increases esr1 expression with sex-specific effects on hmgcr expression, ultimately protecting both sexes from weight gain. Our data suggest that E2 levels regulate hepatic cholesterol synthesis through modulation of hmgcr expression. (B) Findings from Figure 4, with loss of E2-hmgcr regulation upon consumption of a high saturated fat diet.
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