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Fig. 3

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Publication: D'haene et al., 2024 - Comparative 3D genome analysis between neural retina and retinal pigment epithelium reveals differential cis-regulatory interactions at retinal disease loci
All Figures: Figures for D'haene et al., 2024

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Fig. 3

The impact of differential 3D genomic interactions at retinal disease loci. a Number of inherited retinal disease (IRD) genes associated with differential interactions in neural retina vs. RPE/choroid through Hi-C differential regions (CHESS) or loops and HiChIP differential loops. b Single-cell RNA expression per cell type within the adult human retina of two clusters of IRD genes associated with differential interactions. Cell types: rod, L/M cone, S cone, retinal pigment epithelium (RPE), pericyte (PER), fibroblast (FB), endothelial (END), melanocyte (CM), T-cell, microglia (uG), monocyte (MO), mast cell (MAST), ON bipolar (DBC), rod bipolar (RBC), OFF bipolar (HBC), Müller cell (MC), GABA amacrine (ACB), horizontal cell (HC), GLY amacrine (ACY), astrocyte (AST), ganglion cell (GC). c Differential 3D interactions at the CFH and CRB1 locus. d Differential 3D interactions at the MAK locus. e Single-cell RNA expression of genes within highlighted loci in adult human retina (periphery) averaged per cell type group

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