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Figure 4.

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Publication: Guo et al., 2024 - Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior
All Figures: Figures for Guo et al., 2024

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Figure 4.

Alterations in iron metabolism contribute to behavioral abnormalities in the mbd5 germline KO mutant. (A) Schematic of FAC treatment prior to gene expression or behavioral analysis. (B) Quantitative RT-PCR analysis of iron metabolism-associated genes in mbd5^ΔMBD mutants upon FAC treatment. (C, D) Scatter plots of average velocity (C) and average angular velocity (D) in mbd5^ΔMBD mutants treated with FAC. (E) Schematic of DFO treatment. (F) Quantitative RT-PCR analysis of iron metabolism-associated genes in mbd5^ΔMBD mutants upon DFO treatment. (G, H) Scatter plots of average velocity (G) and average angular velocity (H) in mbd5^ΔMBD treated with DFO. All data in (C, D, G, H) represent mean ± SD, N = 36, two-way ANOVA followed by Dunnett's multiple comparisons test. ns, no significance, *P< 0.05, **P< 0.01, ***P< 0.001, ****P< 0.0001.

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