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Fig. 3 Enzymes in the lysosomal multienzyme complex (LMC) are differentially affected in the neu1, gnptab, and galns deficient larvae (A) Schematic of the LMC complex and the diseases each enzyme deficiency causes. (B) Acidic neuraminidase, (C) PPCA, (D) β-galactosidase, and (E) N-acetylgalactosamine 6-sulfatase in neu1, gnptab, and galns deficient animals. n = 3 independent experiments with samples of 15 larvae per genotype. Error = SEM, significance was assessed using the Dunnet’s test, where ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.
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