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Fig. 4 The interaction between cyclin F and TDP-43 is unique. A. The interaction between cyclin F and TDP-43 was maintained when cyclin F carried the cyclin FMRL/AAA mutation. IP represents 50% of eluents. B. Densitometry results of TDP-43 co-immunoprecipitated with cyclin FWT or cyclin FMRL/AAA shown in A. Data represent abundance of co-immunoprecipitated TDP-43 normalised to abundance of immunoprecipitated cyclin F. A student's t-test was used to determine significance. ns; not significant. Results represent the mean and SD from triplicate analyses. C. Flow cytometry evaluation of the effect of cyclin F on inducing SYTOX-positive cells. For all results, N = 3. A Student's t-test was performed to determine significance. *p ≤ 0.05, ns; not significant. Results represent the mean and SD from triplicate analyses.