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Fig 6

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Publication: Bhattarai et al., 2024 - Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease
All Figures: Figures for Bhattarai et al., 2024

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Fig 6

FN1 deposition and gliosis reduce to control levels in APOEε4/4 cognitively unaffected individuals, but not in APOEε4/4 AD patients. a–c Double IFS for FN1 (green) and GFAP (red) with DAPI nuclear counterstain in APOEε3/3 (a), APOEε4/4 AD (b), and APOEε4/4 cognitively unaffected individuals (c). Black–white images are individual fluorescent channels for FN1, GFAP, and DAPI. d–f Two blood vessels in every condition are shown in high magnification together with FN1 channel alone. g FN1 intensity comparisons (2 APOEε3/3 individuals without AD, 2 APOEε4/4 individuals with AD, and 6 APOEε4/4 individuals without AD). h GFAP intensity comparisons. Scale bars equal 50 μm (a-c) and 10 μm (d-f)

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