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Fig 6 Networks of genes involved in collagen synthesis and differentially expressed upon exposure to the total POP mixture.
Networks were generated on Cytomine using GENEMANIA annotations. The nodes represent genes, the fill colors indicate the log2(fold-change) upon POP125× exposure, while the rim circle color gives the log2(fold-induction) due to POP75× exposure. All genes are down-regulated in a dose-dependent way. The edges (connecting lines) represent links between nodes, based on “Shared protein domains” and “Co-expression” in the zebrafish network (left), or on specific interactions and pathways as indicated for the human network (right).