ZFIN Image: Watchon et al., 2024, Fig. 4

Image

Figure Caption

Fig. 4

Immunoblotting of wild-type and transgenic CMVMJD135 mice confirms increased expression of full-length ataxin-3 in the cerebellum of 18-week-old MJD mice. (A) Representative western blot of 18-week-old wild-type and MJD mouse cerebellum following oral vehicle or spermidine supplementation confirming expression of full-length and endogenous ataxin-3. (B) Quantification of full-length ataxin-3 expression shows significant increase in the cerebellum of 18-week-old MJD mice compared to wild-type mice (p < 0.0001, n = 6–7). Expression of full-length ataxin-3 is not significantly altered following vehicle or spermidine treatment. A two-way ANOVA was utilised for statistical analysis followed by Tukey post hoc. Data represents means ± SEM. *** Represents p < 0.0001

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Brain