ZFIN Image: Altbürger et al., 2023, Fig. 6

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Figure Caption

Fig. 6 Ascl1 differentially regulates dlx2a and dlx5a genes. (A–H) Whole-mount in situ hybridization for dlx2a (A-D′) and dlx5a (E-H′) at 48 hpf. Dorsal (A–H) and lateral (A′-H′) views, genotypes as indicated. Anterior is to the left. The expression of dlx2a appears largely unchanged in all genotypes except the posterior hypothalamic region (arrowheads) in the double mutant. The expression of dlx5a is reduced in the telencephalon (filled arrowheads), prethalamus (non-filled arrowheads), and in the hypothalamus. For numbers of analyzed embryos see Supplemental Table S2. Abbreviations: Hyp, hypothalamus; Po, preoptic region; Pth, prethalamus; Tel, telencephalon. Scale bars: 100 μm.

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Reprinted from Developmental Biology, 505, Altbürger, C., Rath, M., Wehrle, J., Driever, W., The proneural factors Ascl1a and Ascl1b contribute to the terminal differentiation of dopaminergic GABAergic dual transmitter neurons in zebrafish, 587458-74, Copyright (2023) with permission from Elsevier. Full text @ Dev. Biol.