ZFIN Image: Baer et al., 2024, Fig 5

Image

Figure Caption

Fig 5 The relationship between DE genes and DAR along the entirety of zebrafish Chromosome 17 in brain transcriptome comparisons of 6-month-old wild type fish against sibling fish heterozygous for either of two different psen1 mutations.

Track A represents the axis of Chromosome 17. The position of psen1 is marked and labelled in bold red. Tracks B and C show the results from the EOfAD-relevant psen1^T428del/+ vs. psen1^+/+ comparison, while tracks D and E show the fAI-relevant psen1^W233fsl/+ vs. psen1^+/+ comparison. Tracks B and D display DE genes from their respective comparisons, while tracks C and E show the trend in DAR as a connected scatterplot with each point representing the DAR value at a single nucleotide variant position (elastic sliding window, n = 11 variants). The positions of DE genes are highlighted on the DAR tracks in a light red colour.

Acknowledgments

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