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Fig. 6 Comparison of cellular lysate and EV proteome. (A) Venn diagram depicting 2139 common proteins in the proteome of OMM2.5 cell lysate and OMM2.5 EV samples. (B) Among the differentially expressed proteins, two common proteins were identified in the OMM2.5 cell lysate and EV samples. (C) Table presenting CHID1 and BCCIP as significantly upregulated (red) in ergolide treated OMM2.5 cell lysate and downregulated (green) in EVs isolated from ergolide treated OMM2.5 cells. (D) Higher BCCIP (p = 0.005) expression levels noted in chromosome 3 (Chr 3) monosomy UM patients, with no difference in CHID1 expression level and Chr 3 status. (E) High or low expression levels of BCCIP and CHID1 did not correlate to overall survival or disease-free survival (DFS) in UM TCGA patient samples.