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Fig. 3 Effect of suramin on thrombin generation induced by Caco-2 cells. Thrombograms represent thrombin generation over time in plasma incubated with Caco-2 cells with basal or overexpression of hepsin and pretreated or not with suramin. These thrombograms show one representative replicate for each condition. Bar graphs show various parameters of these thrombograms and represent the mean and standard deviation of five different replicates. Statistical differences were analyzed by the unpaired t-test. Caco-2-EV: Caco-2 cells with basal expression of hepsin; Caco-2-HPN: Caco-2 cells with hepsin overexpression; ETP: endogenous thrombin potential; ns: not significant differences; * ** : p-value < 0.001; * *: p-value < 0.01; * : p-value < 0.05.