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Fig. S12 Local environment of sugar moieties of glycosyl-Q on the ribosome, related to Figure 6 (A–D) Models of glycosyl-Qs at the A-site. Local environment of sugar moieties of manQ34 in the human 80S ribosome (PDB: 8JDK ) (A) and in the E. coli 70S ribosome (PDB: 7Y7E) (B), and galQ34 in the human 80S ribosome (PDB: 8JDM) (C) and in the E. coli 70S ribosome (PDB: 7Y7G ) (D). (E–G) Models of glycosyl-Qs at the P-site of human 80S ribosome. Local environment of sugar moieties of manQ34 (PDB: 8JDK ) (E) and galQ34 in the classical state (PDB: 8JDL) (F) and in the hybrid state (PDB: 8JDM) (G) at the P-site. Distances between two atoms are depicted by dotted arrows.
Reprinted from Cell, 186(25), Zhao, X., Ma, D., Ishiguro, K., Saito, H., Akichika, S., Matsuzawa, I., Mito, M., Irie, T., Ishibashi, K., Wakabayashi, K., Sakaguchi, Y., Yokoyama, T., Mishima, Y., Shirouzu, M., Iwasaki, S., Suzuki, T., Suzuki, T., Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth, 5517-5535.e24, Copyright (2023) with permission from Elsevier. Full text @ Cell