IMAGE

Fig. 4

ID: ZDB-IMAGE-240203-8
Publication: Williams et al., 2024 - GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment
All Figures: Figures for Williams et al., 2024

Image

Figure Caption

Fig. 4

RNA-seq of PDX GBM indicates OGM induces ferroptosis. (A) Heatmap of gene expression changes shows broad changes in transcriptomes in PDX cells after treatment. (B) PCA comparison of transcriptomes demonstrates that differences across cell types are greater than differences induced by OGM treatment. This difference is also shown through hierarchical clustering in (C). (D) SDE genes from 913, 08-387, and Mayo PDX cells after OGM treatment were 837, 687, and 309, respectively (FDR < 0.01). (E) Comparison of SDE genes found that only 7 common genes were dysregulated in all three treatment groups. (F) String analysis of 7 commonly dysregulated genes. (G) Subset of Gene set enrichment analysis of terms implicates ferroptosis as a mechanism of cell death (full analysis in Fig. S12)

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Exp Hematol Oncol