IMAGE

Fig. 6

ID
ZDB-IMAGE-240203-10
Publication
Williams et al., 2024 - GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment
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Figures for Williams et al., 2024
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Figure Caption

Fig. 6

Loss of GPR68 causes ferroptosis in GBM. (A) OGM decreased GSH levels in U87 cells. (B, C) OGM significantly increased lipid peroxidation in U87 and U138. Chi square T(X) > 4 is considered significant. (D) OGM disrupted Mitochondria structure (Mitotracker) and function (TMRM) in U87, but not lysosome structure (Lysotracker). (E) Quantification of TMRM in U87 and U138. (F) Ultrastructure of U87 cells treated with OGM show disrupted mitochondria: *, but normal ER (arrowhead)

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Exp Hematol Oncol
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