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Fig. 2 Zebrafish fbxo3 suppresses expression of IFN and ISGs induced by poly(I:C) stimulation and SVCV infection. (A–C) Overexpression of fbxo3 suppressed expression of ifn (A), viperin (B), and isg15 (C) induced by poly(I:C) (1 μg/ml) in EPC cells. (D–F) Overexpression of fbxo3 suppressed expression of ifn (D), viperin (E), and isg15 (F) induced by SVCV (∼1.00 × 108 TCID50 per milliliter) infection in EPC cells. Data are presented as means ± SEM of three biological replicates. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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Full text @ J. Immunol.