ZFIN Image: Liao et al., 2023, Figure 1

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Figure 1

Phylogenetic analysis of PHD3 proteins and the expression pattern of zebrafish phd3 in different tissues.A, alignment of PHD3 amino acid sequences of Homo sapiens (Hs) and Danio rerio (Dr). B, the phylogenetic tree of PHD3 proteins from 12 species was constructed using the neighbor-joining method. Homo sapiens (Hs), NM_022073.4; Mus musculus (Mm), NM_028133.2; Gallus gallus (Gg), XM_421233.6; Apteryx rowi (Ar), XM_026085427.1; Latimeria chalumnae (Lc), XM_005989196.2; Xenopus tropicalis (Xt), NM_001127012.1; Danio rerio (Dr), NM_213310.1; Oryzias latipes (Ol), XM_023951862.1; Takifugu rubripes (Tr), XM_029833019.1; Pseudonajia textilis (Pt), XM_026710948.1; Erpetoichthys calabaricus (Ec), XM_028821616.1; and Drosophila melanogaster (Dm), NM_001300242.1. C, the predicted protein structure of zebrafish phd3 by AlphaFold in Ensembl database (https://www.asia.ensembl.org/index.html). D, quantitative real-time PCR (qPCR) analysis of phd3 mRNA levels in different tissues of adult zebrafish (5 months post-fertilization, mpf).

Acknowledgments

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