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Fig. 7 Plxnd1 signalling regulates lymphatic vessel guidance and growth. Model of Plxnd1-mediatated regulation of lymphatic development. (A) In the head, Plxnd1 signalling antagonises Vegfr/Erk signalling to prevent facial lymphatic hyperplasia. It also prevents aberrant cell migration. The role and identity of semaphorin ligands in facial lymphatic development are yet to be determined. (B) In the trunk, Plxnd1 signalling within developing ISLVs, likely triggered by Sema3aa/Sema3c ligands, prevents migration into the somites.
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