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Figure Caption
Fig. 6 Model for the mechanism of statin-mediated expansion of zebrafish craniofacial tendon program. Schematic illustrates selected craniofacial cartilage, muscle and tendon/ligament groups in ventral view of DMSO- and statin-treated zebrafish at 56 hpf after incubation from 32 to 56 hpf. Exposure of multipotential chondrocyte-tendon progenitors to statins results in re-specification towards a tendon fate – a process mediated through RAC GTPase inhibition. This cell fate expansion is spatially restricted to subsets of CNC-derived elements.
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