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Fig. 3 Working Model of the effect of rab28 KO on the zebrafish retina. From the published results, the hypothesis stands that A2PE is elevated within the rab28 KO photoreceptor OS due to the defective OSP phenotype and lower levels of Abca4b in rab28 KO. Accumulation and formation of A2PE may contribute to photoreceptor cell dysfunction. (Kim et al., 2006) Figure created using BioRender.com
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Reprinted from Vision Research, 210, Moran, A.L., Fehilly, J.D., Blacque, O., Kennedy, B.N., Gene therapy for RAB28: What can we learn from zebrafish?, 108270108270, Copyright (2023) with permission from Elsevier. Full text @ Vision Res.