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Fig. 6.

ID: ZDB-IMAGE-231126-4
Publication: Bravo et al., 2023 - Macrophage activation drives ovarian failure and masculinization in zebrafish
All Figures: Figures for Bravo et al., 2023

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Figure Caption

Fig. 6. Il34 and Csf1a differentially contribute to ovarian failure and sex reversal and macrophages persist in csf1a- and il34-mutant ovaries.

(A and B) Live tissue images of adult gonads of indicated genotypes. Scale bar, 500 μm. (C) Graph with adult sex ratios of indicated genotypes. Female, pink; male, blue. Numbers indicate individuals examined. Statistical analysis: chi-square test with Bonferroni correction; P value comparisons to bmp15^+/−, ***P ≤ 0.0001. (D to O) Immunostained adult gonads of (E) to (J) ligand single mutants, and (K) to (O) bmp15;ligand DMs of indicated genotypes. Aif1l (yellow) labels macrophages, Ddx4 (magenta) labels germ cells, and DAPI (blue) labels DNA. Dotted lines mark macrophages. Scale bars, 100 μm.

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