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Figure 8.
An early ground state that lacks an anteroposterior pattern is proposed to respond to morphogens (fibroblast growth factor (Fgf) anteriorly and retinoic acid posteriorly) to generate three PHPDs. Each PHPD contains progenitor cells with mixed identities (HB.1=r1, r2, r3; HB.2=r5, r6, HB.3=r4) that are subsequently resolved via repressive TF interactions (red lines) into rhombomere cells with a single transcriptional identity.
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