ZFIN Image: Finotto et al., 2023, Figure 5

Image

Figure Caption

Figure 5 Overview of different zebrafish avatars

A

Schematic overview showing the timeline of the orthotopic zebrafish xenograft model.

B

Zoomed‐in images of round (left) and ramified (right) GAMs in the recorded time‐lapse movies. Scale bars: 15 μm.

C–J

Representative maximum intensity projections of a z stack of the head region of Tg(mpeg1:mCherryF)^ump2; Tg(kdrl:lynEYFP)^md77 zebrafish embryos with different GFP‐labeled patient‐derived GSCC tumors, at 1 dpi (left panel) and 5 dpi (right panel): BT333 (C), BT569 (D), CME037 (E), CME038 (F), LBT001 (G), LBT003 (H), LBT070 (I), LBT123 (J). GBM tumor cells are shown in green, GAMs in red, and blood vessels in blue. Arrows indicate midline protrusion of the tumor. Filled arrowheads indicate round GAMs. Open arrowheads indicate ramified GAMs. Scale bars: 50 μm.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.