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Figure 4—figure supplement 1

ID: ZDB-IMAGE-231116-107
Publication: Shrestha et al., 2023 - The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra) - phosphoinositide 3-kinase (PI3K) signaling cascade to steer towards the midline during zebrafish heart tube formation
All Figures: Figures for Shrestha et al., 2023

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Figure Caption

Figure 4—figure supplement 1 Different types of myocardial protrusion morphologies occur during cardiac fusion.

Snapshots from timelapse videos of myocardial cells mosaically labeled with myl7:lck-eGFP in a DMSO- (A) or a LY- (B) treated embryo. Purple arrowheads and green arrows indicate thin and wide protrusions, respectively. (C) Rose plots display the orientation of thin and wide protrusions in DMSO- (left) or LY- (right) treated embryos. Forward/medial direction: 270–90°. Backward/lateral direction: 90–270°. (D) Graphs indicate the average percentage of thin (purple dots) or wide (green dots) protrusions per cell per hour. Dots = individual cells. n = 425 protrusions from 11 cells in 5 embryos (DMSO), and 480 protrusions from 11 cells in 4 embryos (20 µM LY). Fisher’s exact test, p-value 3.866e-08. Mean ± standard deviation. Raw data included in the source file.

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