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Fig. 9
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- ZDB-IMAGE-231107-40
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- Demers et al., 2022 - PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS
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- Figures for Demers et al., 2022
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Fig. 9 Model of PEX13 induction of pexophagy. In this model, we propose that the loss of PEX13 3 (∆PEX13) promotes pexophagy by i) the accumulation of ubiquitinated PEX5 on the peroxisomal membrane that recruits autophagy receptors and ii) increasing cellular ROS levels to upregulate autophagosome formation. PEX13-dependent pexophagy can be observed during amino acid starvation or when MTORC1 is pharmaceutically inhibited.
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