Fig. 2 Major steroidogenic pathways in zebrafish. Key enzymes are shown near the arrow heads at each step of the biosynthetic pathway. The hexagons near key enzymes indicate that BPA may affect steroid synthesis by affecting these enzymes. (StAR: steroidogenic acute regulatory protein; CYP11a1: cytochrome P450 family 11 subfamily A member 1; CYP11c1: cytochrome P450 family 11 subfamily C member 1; CYP17a1: cytochrome P450 family 17 subfamily A member 1; CYP19a1: cytochrome P450, family 19, subfamily A, polypeptide 1; CYP21a2: cytochrome P450 family 21 subfamily A member 2; HSD3b: hydroxy-delta-5-steroid dehydrogenase, 3 beta; HSD11b2: hydroxysteroid (11-beta) dehydrogenase 2; HSD17b1: hydroxysteroid (17-beta) dehydrogenase 1; HSD20b: hydroxysteroid (20-beta) dehydrogenase).
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