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Figure 3

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Publication: Toualbi et al., 2023 - Gene Augmentation of CHM Using Non-Viral Episomal Vectors in Models of Choroideremia
All Figures: Figures for Toualbi et al., 2023

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Figure 3

Micro-injection of chm^ru848 zebrafish with pS/MAR-CHM. Wholemount color and fluorescent images of (A) wild-type, (B) chm^ru848, (C) pS/MAR-CMV-CHM-injected wild-type, and (D) pS/MAR-CMV-CHM-injected chm^ru848 zebrafish at 5 days post-fertilization. (E) Comparison of survival in injected and un-injected chm^ru848 zebrafish larvae. (F) Western blot for human-specific REP1 protein with the 2F1 antibody in injected and un-injected chm^ru848 zebrafish larvae. Human REP1 was detected in the injected zebrafish only. (G) Prenylation assay to detect levels of un-prenylated Rabs in wild-type, injected, and un-injected chm^ru848 zebrafish larvae (* = p < 0.05; *** = p < 0.001).

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