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FIGURE 6

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ZDB-IMAGE-231004-37
Publication
Zhao et al., 2023 - The prolyl isomerase Pin1 stabilizes NeuroD during differentiation of mechanoreceptors
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Figures for Zhao et al., 2023
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Figure Caption

FIGURE 6

Pin1 regulates Nrd stability. Protein stability assay of HA-Nrd in HEK 293T cells stably expressing control siRNA and Pin1 siRNA. (A) HA-Nrd degraded at a higher rate in Pin1 knock-down background in HEK 293T cell line. (B) HA-Nrd5A levels remained stable in Pin1 knock-down background in HEK 293T cells. (C) Overexpression of FLAG-tagged zebrafish Pin1 enhanced Nrd stability. α-tubulin was used as an internal control. (D) Quantification of HA-Nrd levels in (A,C) normalized to α-tubulin levels. (E) Quantification of HA-Nrd levels in (B) normalized to α-tubulin levels. Error bars represent ±SEM.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol
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