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Publication: Zhai et al., 2023 - Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis
All Figures: Figures for Zhai et al., 2023

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Fig 10 Interaction of bmp15 and gdf9 in zebrafish follicle development.

(A) Histological analysis of bmp15 and gdf9 single and double mutants at 90 dpf. The follicles of some double mutants (gdf9-/-;bmp15-/-) could overcome the blockade at PG to enter early PV (PV-I) stage. (B) Partial rescue of vitellogenic growth in bmp15 and gdf9 single and double mutants by inha-/-. (C) Follicle distribution in different genotypes. Simultaneous mutation of inha-/- could rescue the follicle growth in both bmp15-/- and gdf9-/- to MV stage; however, further loss of inhbaa reduced it to EV stage. (D) Follicle composition in different genotypes and the data are shown as mean ± SEM (n = 3). Statistical analysis was performed with ANOVA followed by Tukey HSD for comparison with corresponding stages in the control fish (* P < 0.05; ** P < 0.01; *** P < 0.001). The proportion of PV-I follicles was significantly higher in the double mutant (gdf9-/-;bmp15-/-) than others especially gdf9-/- single mutant. The proportion of follicles at EV-FG stage (stage III) was lower in the triple mutants than the double mutant (gdf9-/-;bmp15-/-).

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