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Publication: Sarkar et al., 2023 - Oxidative and Endoplasmic Reticulum Stress Represent Novel Therapeutic Targets for Choroideremia
All Figures: Figures for Sarkar et al., 2023

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Figure 2

Increased ER and oxidative stress in CHM^Y42X patient fibroblasts. (A) The expression of ER stress markers was analysed in WT and CHM fibroblasts using RT-qPCR. Data expressed as mean ± SEM from n = 3. (B) Representative western blot showing reduced BIP protein expression in CHM fibroblasts. (C) Quantification of BIP protein from n = 3 blots. (D) The expression of oxidative stress markers was analysed using RT-qPCR. (E) No significant difference in the SOD enzyme activity between WT and CHM fibroblasts. Data expressed as mean ± SEM from n = 3 (denoted by black dots for wt and black squares for chm fish). * p ≤ 0.05, ** p ≤ 0.01.

Acknowledgments

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