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Fig. 8

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Publication: Riesle et al., 2023 - Activator-blocker model of transcriptional regulation by pioneer-like factors
All Figures: Figures for Riesle et al., 2023

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Fig. 8 Synergistic and antagonistic Pou5f3/Nanog direct enhancers: the mechanism of action and direct target genes.

a Synergistic enhancers Pou5f3+Nanog + : Pou5f3 and Nanog act as activators. b Antagonistic enhancers Pou5f3+Nanog-: Pou5f3 acts as an activator, Nanog as a blocker. c Antagonistic enhancers Pou5f3-Nanog + : Nanog acts as an activator, Pou5f3 as a blocker. Representative early targets (expressed in the wild-type during 2.5-6 hpf time course), and late targets (prematurely expressed in the mutants by blocker TF during 2.5-6 hpf time course) are indicated by schematic early and late embryo drawings. Source data are provided as a Source Data file 3. Zebrafish embryo drawings were used with permission of John Wiley & Sons - Books, from “Stages of Embryonic Development of the Zebrafish”, Kimmel et al., Developmental Dynamics 203:253-310 (1995); permission conveyed through Copyright Clearance Center, Inc.

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