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Fig. 1
Palladium-mediated bioorthogonal bond cleavage strategies. (A) Palladium-mediated N/O-deallylation and depropargylation reactions for the activation of masked small molecules, proteins, and bioconjugates. (B) Specific enzymatic trigger, an acid-promoted, self-immolative C?C bond-cleaving 1,6-elimination mechanism releases ?-lapachone.30 (C) This work, the decaging of the prodrug propargyl ?-lapachone, through a palladium(II) nanoparticles-mediated C?C bond cleavage.
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Full text @ J. Am. Chem. Soc.