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Elsaid et al., 2023 - Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla^-/- zebrafish model of Fabry disease

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Fig. 4

Immunohistochemical analysis of the expression of selected proteins in wild-type and mutant zebrafish renal tissues. A Representative image of IHC analysis targeting mitochondrial marker Sod2 and lysosomal marker Cd63 in kidneys from wild-type and mutant ZF renal tissues; B Quantification of immunohistochemical staining of sections from wild-type and mutant ZF kidneys. Signal intensity is significantly higher in wild-type than in mutant specimens for CD63 and Sod2; C Heatmap showing protein expression of CD63) and Sod2 in mutant and wild-type kidney tissues, normalized as percent of positive pixels. Data analysis using Mann–Whitney test; **p-value ≤ 0.001

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Transl Med