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Fig. 4.

ID: ZDB-IMAGE-230916-16
Publication: Kim et al., 2023 - Intrinsic and extrinsic regulation of rhabdomyolysis susceptibility by Tango2
All Figures: Figures for Kim et al., 2023

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Figure Caption

Fig. 4.

tango2 mutants exhibit increased sensitivity to caffeine-induced SR stress that is partially reversed by dantrolene. (A) Schematics for caffeine treatment. (B) Effect of caffeine treatment on total swimming distance by control and tango2 mutants. n=96. (C) Effect of dantrolene (‘D’) treatment on motor function in caffeine (‘C’)-treated control and tango2 mutants. Data were normalized to swimming distance before caffeine treatment within each group. n=48 in each group with 10-22 different genotypes. Data represent mean±s.e.m. Two-way ANOVA (mixed model) with multiple comparisons was performed between different groups. ns, not significant; *P<0.05, **P<0.01. (D) Whole-mount phalloidin staining (green) of control and tango2 mutants exposed to caffeine and dantrolene. Arrowheads indicate misaligned myofibers and arrows indicate damaged myofibers. Nuclei are shown in blue. Images are representative of n=6 larvae in each group. Scale bar: 5 µm.

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Phenotype details

Acknowledgments

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