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Fig. 3
Exportin 1 (XPO1) inhibitors begin to induce decreased tet2-mutant haematopoietic stem and progenitor cells (HSPCs) in the caudal haematopoietic tissue (CHT) region at 3 days post fertilisation (dpf). (A) Embryos with the indicated genotypes were treated with either dimethylsulfoxide (DMSO), selinexor (100 nM) or eltanexor (250 nM) dissolved in fish water from 1?3 dpf. Whole-mount in situ hybridisation was performed using a riboprobe for c-myb at 3 dpf and images were taken. Boxes in each of the images magnify staining in the CHT region. (B) Quantification of c-myb expression in the CHT region as described in panel A.
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Full text @ Br. J. Haematol.