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Fig. 4
bECs targeting by PAP3 liposomes is inhibited by heparin and an EL lipase inhibitor. a) Timeline of injection and imaging. b,c) Biodistribution (10x and 40x magnification) of PAP3 liposomes at 1.5 hpi, after heparin (1 nl, 50 mg ml−1) administration. d) Timeline of injection and imaging. e,f) Biodistribution (10x and 40x magnification) of PAP3 liposomes, as a reference, at 1.5 hpi. g) Timeline of injection and imaging. h,i) Biodistribution (10x and 40x magnification) of PAP3 liposomes at 1.5 hpi, after a double administration (24 and 1 h prior liposome injection) of an EL inhibitor (XEN445, 1 nL of 50 µM). All zebrafish larvae, Tg(kdrl:GFP) at ≈78 hpi. Liposomes (5 mM, 0.2% mol DOPE-LR) formulated by extrusion. Scale bars: 200 µm (whole embryo) and 50 µm (tissue level).
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