Figure 3

Figure 3

I_Ks inhibitors prolong more zebrafish AP after drug-induced LQT2. (A) Representative zebrafish AP traces before (black) and after applying E4031 (red, 10 µM), and E4031/chromanol 293B (10 µM/100 µM, dark purple). (B) ΔAPD80 (%) measured at different recording times vs. E4031 control condition (10, 20, and 30 min after application of E4031/chromanol 293B). (C) ΔAPD (%) produced by the combination of drugs measured for the APD25, APD50, APD80, and APD90. (D) Effect of the combination of drugs on phase 3 of the AP. APD80–APD25 in E4031 (control conditions) and after E4031/chromanol 293B application. (E–H) The same as in (A–D) but for the combination E4031/JNJ303 (10 µM/10 µM) (mean ± SEM; ^#p < 0.05 vs. E4031 condition, ^Φp < 0.05 APD80 time data average vs. E4031 condition). Each symbol in panels D and H represent data from a different experiment.