ZFIN Image: Siddiqui et al., 2023, Fig. 3

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Figure Caption

Fig. 3 Lv16 transduction enhances neurogenesis in wild type and APP/PS1dE9 mouse model of Alzheimer’s disease.

a Dcx, mCherry, and BrdU triple immunostaining with DAPI counterstain in Lv13-transduced wild type mouse dentate gyrus. a1. mCherry channel of a. a2. Dcx and DAPI channel of a. a3. BrdU channel of a. b Dcx, mCherry, and BrdU triple immunostaining with DAPI counterstain in Lv16-transduced wild type mouse dentate gyrus. b1. mCherry channel of b. b2. Dcx and DAPI channel of b. b3. BrdU channel of b. c Dcx, mCherry, and BrdU triple immunostaining with DAPI counterstain in Lv13-transduced APP/PS1dE9 mouse dentate gyrus. c1. mCherry channel of c. c2. Dcx and DAPI channel of c. c3. BrdU channel of c. d Dcx, mCherry, BrdU triple immunostaining with DAPI counterstain in Lv1613-transduced APP/PS1dE9 mouse dentate gyrus. d1. mCherry channel of d. d2. Dcx and DAPI channel of d. d3. BrdU channel of d. e Normalized values of Dcx-positive, BrdU-Dcx double positive and BrdU-Dcx-mCherry triple positive cells in wild type mouse dentate gyrus transduced with Lv13 (control) or Lv16 (NGFR). f Normalized values of Dcx-positive, BrdU-Dcx double positive and BrdU-Dcx-mCherry triple positive cells in APP/PS1dE9 mouse dentate gyrus transduced with Lv13 (control) or Lv16 (NGFR). Scale bars equal 50 μm. Error bars represent standard error of the means, with each point representing one section. Y-axes represent numbers per mm². 3 mice were used.

Acknowledgments

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