IMAGE

Fig. 8

ID
ZDB-IMAGE-230712-14
Source
Figures for Siddiqui et al., 2023
Image
Figure Caption

Fig. 8 Schematic view of the NGFR/LCN2/SLC22A17-dependent neurogenic switch mechanism in astroglia.

Nerve growth factor receptor can convert reactive astroglia to neurogenic state in mouse model of Alzheimer’s disease (AD) through suppression of Lcn2 activity on Slc22a17 receptor. In AD cohorts in humans, NGFR is co-expressed with a weighed expression cluster including PFKP, blockage of which enhances neurogenesis from astroglia. In zebrafish, Ngfr activity determines the neuroregenerative potential after amyloid toxicity. We propose an evolutionarily conserved mechanism relating to neurogenesis-related brain resilience in vertebrates.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NPJ Regen Med
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