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Figure 5—figure supplement 3.

ID: ZDB-IMAGE-230707-74
Source: Figures for Chen et al., 2023

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Figure Caption

Figure 5—figure supplement 3. Expression of TP53^P153Δ with kRAS^G12D in tp53^-/- zebrafish results in the initiation of medulloblastomas with a shh gene signature. (TP53^P153Δ).

(A) Representative images of tp53^-/- fish with head embryonal rhabdomyosarcoma (ERMS) tumors, expressing TP53^P153Δ (DsRED positive). The zebrafish in (A) are between 25 and 50 d. Scale bar = 1 mm. (B) H&E of the head regions of tp53^-/- fish with head ERMS tumors, expressing TP53^P153Δ. (C) H&E stained sections at ×20 magnification of tp53^-/- fish with head ERMS tumors, expressing TP53^P153Δ. (D) IHC for myosin heavy chain at ×20 magnification of tp53^-/- fish with head ERMS tumors, expressing TP53^P153Δ. Scale bar = 100 µm.

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