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Publication: Sveinsdóttir et al., 2022 - Novel non-stimulants rescue hyperactive phenotype in an adgrl3.1 mutant zebrafish model of ADHD
All Figures: Figures for Sveinsdóttir et al., 2022

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Fig. 2 Effects of ADHD therapeutics on adgrl3.1^−/− mutants.

adgrl3.1^−/− larvae were treated with three different concentrations (1 µM, 10 µM, and 30 µM) of A clonidine, B atomoxetine, and C guanfacine and compared to larvae treated with 0.3% DMSO. Average distance moved during the five 30-min periods of lights-on and sleep parameters during the night was analyzed. Clonidine, atomoxetine and guanfacine all reduced the distance moved during lights-on significantly for all three concentrations. Clonidine, atomoxetine, and guanfacine all significantly altered the sleep dynamics at multiple parameters during the night. Wild-type (WT) larvae treated with 0.3% DMSO are included for visual comparison. * denote significant differences.

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Phenotype details

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