ZFIN Image: Tabler et al., 2022, Fig. 10

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Figure Caption

Fig. 10

Loss of Glo2 leads to reduced P70–S6 kinase phosphorylation and hexose content in the liver. The knockout of glyoxalase 2 via CRISPR-Cas9 did not affect the redox status or impair the survival and general development of glo2^−/− zebrafish. The liver, the organ with the highest glo2 expression, showed reduced P70–S6 kinase phosphorylation and reduced glucose concentrations, while AKT phosphorylation remained unaffected. Blood glucose remained normal. Skeletal muscle showed a strong increase of glucose concentrations, glycolysis and TCA cycle activity. Gluconeogenesis in contrast was downregulated. The retinal vasculature and kidneys did not show altered morphology and architecture.

Acknowledgments

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