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Publication: Grabinski et al., 2023 - Comparative analysis of transcriptional changes in zebrafish cep290 and bbs2 mutants by RNA-seq reveals upregulation of inflammatory and stress-related pathways
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Figure 1

Differentially expressed genes (DEGs) in retinas of cep290^−/− and bbs2^−/− versus wild-type zebrafish regulate similar biological processes. (A) Upregulated (red) and downregulated (blue) DEGs in retinas from 6 mpf bbs2^−/− and cep290^−/− mutants compared to wild-type siblings. (B) Heat map showing the standardized gene counts of DEGs in all samples (n = 5,522) and hierarchically clustered by sample. The length of the branch is proportional to the difference in transcript levels between samples. (C) Heat map of all downregulated PANTHER Biological processes based on DEGs from cep290 and bbs2 mutant retinas. (D) Heat map of all upregulated PANTHER Biological processes based on DEGs from cep290 and bbs2 mutant retinas.

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