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Fig 1
ZfpA impacts virulence in wild-type but not neutrophil-deficient hosts.
Survival analysis of larvae with the dominant negative Rac2D57N neutrophil mutation (neutrophil-deficient) or wild-type siblings injected with PBS, WT CEA10, ΔzfpA, or OE::zfpA strains. WT larvae average spore dose injected: WT CEA10 = 60, ΔzfpA = 50, OE::zfpA = 62. Rac2D57N larvae average spore dose injected: WT CEA10 = 52, ΔzfpA = 54, OE::zfpA = 53. Results represent pooled data from 3 independent replicates. n = 71–72 larvae per condition. p values and hazard ratios calculated by Cox proportional hazard regression analysis.
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