ZFIN Image: Mignani et al., 2023, Figure 4

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Figure 4

Histological analysis of intestinal epithelium in adult fish. (A) Growth curve of ap1g1^+/+ and ap1g1^+/−. Body weight (in gr) was measured at different ages of adult life from 3 to 18 months. Both males’ and females’ ap1g1^+/− body weight is significantly lower compared to ap1g1^+/+. Statistical significance was determined by multiple t-test comparing each age group. For each group, 10 individuals were used and data was derived from two different experimental groups. (B) Histological analysis of ap1g1^+/+ and ap1g1^+/− intestinal mucosa with abnormal epithelium at the villous tips and reduced height of villi in the heterozygous mutant at 9 months age-old compared to wild-type homozygous fish. Scale bar = 100 μm Abbreviations: im: intestinal mucosa; gc: globet cells.

Acknowledgments

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